a conditional random field approach that combines sequence and structural information
significantly improves the prediction of protease substrate cleavage sites
Input the substrate sequence (example)
Please select the protease of interest from the dropdown menu to make the prediction: (help)
select all pepsin A (A01.001) cathepsin D (A01.009) cathepsin E (A01.010) rhizopuspepsin (A01.012) aspergillopepsin I (A01.016) necepsin-1 (A01.053) HIV-1 retropepsin (A02.001) cathepsin L (C01.032) cathepsin S (C01.034) cathepsin K (C01.036) falcipain-2 (C01.046) cathepsin B (C01.060) falcipain-3 (C01.063) cathepsin L3 ({Fasciola} sp.) (C01.129) calpain-1 (C02.001) calpain-2 (C02.002) caspase-1 (C14.001) caspase-3 (C14.003) caspase-7 (C14.004) caspase-6 (C14.005) caspase-8 (C14.009) matrix metallopeptidase-1 (M10.001) matrix metallopeptidase-8 (M10.002) matrix metallopeptidase-2 (M10.003) matrix metallopeptidase-9 (M10.004) matrix metallopeptidase-3 (M10.005) matrix metallopeptidase-7 (M10.008) matrix metallopeptidase-12 (M10.009) matrix metallopeptidase-13 (M10.013) membrane-type matrix metallopeptidase-1 (M10.014) astacin (M12.001) meprin alpha subunit (M12.002) meprin beta subunit (M12.004) LAST peptidase ({Limulus polyphemus}) (M12.032) LAST_MAM peptidase (M12.033) ADAMTS4 peptidase (M12.221) insulysin (M16.002) mitochondrial processing peptidase beta-subunit (M16.003) chymotrypsin A (cattle-type) (S01.001) granzyme B ({Homo sapiens}-type) (S01.010) kallikrein-related peptidase 5 (S01.017) elastase-2 (S01.131) cathepsin G (S01.133) granzyme A (S01.135) granzyme B, rodent-type (S01.136) thrombin (S01.217) plasmin (S01.233) kallikrein-related peptidase 4 (S01.251) glutamyl peptidase I (S01.269) lysyl peptidase (bacteria) (S01.280) lactocepin I (S08.019) kexin (S08.070) furin (S08.071) PCSK-1 peptidase (S08.072) PCSK-2 peptidase (S08.073) PCSK-4 peptidase (S08.074) PCSK-6 peptidase (S08.075) PCSK-5 peptidase (S08.076) PCSK-7 peptidase (S08.077) KPC2-type peptidase (S08.109) lactocepin-3 (S08.116) signal peptidase I (S26.001) signalase (animal) 21 kDa component (S26.010)
If you find Procleave useful, please kindly cite our paper:
Li et al. "Procleave: a conditional random field approach that combines sequence and structural information significantly improves the prediction of protease substrate cleavage sites", Genomics Proteomics Bioinformatics, 2020 Feb;18(1):52-64. doi: 10.1016/j.gpb.2019.08.002.
Copyright © 2019. Biomedicine Discovery Institute and School of Biomedical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Australia
